Cargando…

APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer’s disease with Lewy body pathology

Approximately half of Alzheimer’s disease (AD) brains have concomitant Lewy pathology at autopsy, suggesting that α-synuclein (α-SYN) aggregation is a regulated event in the pathogenesis of AD. Genome-wide association studies revealed that the ε4 allele of the apolipoprotein E (APOE4) gene, the stro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jin, Yunjung, Li, Fuyao, Sonoustoun, Berkiye, Kondru, Naveen Chandra, Martens, Yuka A., Qiao, Wenhui, Heckman, Michael G., Ikezu, Tadafumi C., Li, Zonghua, Burgess, Jeremy D., Amerna, Danilyn, O’Leary, Justin, DeTure, Michael A., Zhao, Jing, McLean, Pamela J., Dickson, Dennis W., Ross, Owen A., Bu, Guojun, Zhao, Na
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2022
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107450/ https://www.ncbi.nlm.nih.gov/pubmed/35471463 http://dx.doi.org/10.1007/s00401-022-02421-8

Ejemplares similares

ApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies
por: Raulin, Ana-Caroline, et al.
Publicado: (2022)

Enrichment of Phosphorylated Tau (Thr181) and Functionally Interacting Molecules in Chronic Traumatic Encephalopathy Brain-derived Extracellular Vesicles
por: Muraoka, Satoshi, et al.
Publicado: (2021)

Comprehensive characterization of human brain‐derived extracellular vesicles using multiple isolation methods: Implications for diagnostic and therapeutic applications
por: Zhang, Zhengrong, et al.
Publicado: (2023)

The neuropathological diagnosis of Alzheimer’s disease
por: DeTure, Michael A., et al.
Publicado: (2019)

Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination
por: Wang, Na, et al.
Publicado: (2022)

APOE2: protective mechanism and therapeutic implications for Alzheimer’s disease
por: Li, Zonghua, et al.
Publicado: (2020)

APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids
por: Zhao, Jing, et al.
Publicado: (2023)

Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia
por: Zhao, Na, et al.
Publicado: (2022)

Three Repeat Isoforms of Tau Inhibit Assembly of Four Repeat Tau Filaments
por: Adams, Stephanie J., et al.
Publicado: (2010)

Clinicopathologic and genetic features of multiple system atrophy with Lewy body disease
por: Koga, Shunsuke, et al.
Publicado: (2020)

TDP-43 Pathology in Alzheimer’s Disease
por: Meneses, Axel, et al.
Publicado: (2021)

Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies
por: Bras, Jose, et al.
Publicado: (2014)

ApoE and apoE receptors in brain lipid metabolism and AD
por: Bu, Guojun
Publicado: (2012)

APOE2 is associated with longevity independent of Alzheimer’s disease
por: Shinohara, Mitsuru, et al.
Publicado: (2020)

Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson’s disease brains with Lewy body pathology
por: Mamais, Adamantios, et al.
Publicado: (2018)

The Effect of GBA Mutations and APOE Polymorphisms on Dementia with Lewy Bodies in Ashkenazi Jews
por: Shiner, Tamara, et al.
Publicado: (2021)

Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samples
por: Watzlawik, Jens O., et al.
Publicado: (2020)

Alpha-Synuclein Oligomers—Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders
por: Ingelsson, Martin
Publicado: (2016)

α-Synuclein filaments from transgenic mouse and human synucleinopathy-containing brains are major seed-competent species
por: Morgan, Sophie A., et al.
Publicado: (2020)

Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress
por: Zhang, Yong-Jie, et al.
Publicado: (2014)

APOE ε4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia
por: Mirza, Saira Saeed, et al.
Publicado: (2019)

Impact of APOE ε4 genotype on initial cognitive symptoms differs for Alzheimer’s and Lewy body neuropathology
por: Pillai, Jagan A., et al.
Publicado: (2021)

Vascular hypothesis of Alzheimer’s disease: role of apoE and apoE receptors
por: Bu, Guojun, et al.
Publicado: (2013)

Standardized immunoprecipitation protocol for efficient isolation of native apolipoprotein E particles utilizing HJ15.4 monoclonal antibody
por: O’Leary, Justin, et al.
Publicado: (2023)

APOE ε2 is associated with increased tau pathology in primary tauopathy
por: Zhao, Na, et al.
Publicado: (2018)

Death Adder Envenoming Causes Neurotoxicity Not Reversed by Antivenom - Australian Snakebite Project (ASP-16)
por: Johnston, Christopher I., et al.
Publicado: (2012)

369 Differentiating Dementia with Lewy Bodies and Alzheimer’s Disease Using Extracellular Vesicles
por: Bregendahl, Maria, et al.
Publicado: (2023)

Neuropathology and molecular diagnosis of Synucleinopathies
por: Koga, Shunsuke, et al.
Publicado: (2021)

Early childhood learning patterns for a home visiting program in rural China
por: Zhou, Jin, et al.
Publicado: (2022)

GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study
por: Rongve, Arvid, et al.
Publicado: (2019)

A Mutant Methionyl-tRNA Synthetase-Based toolkit to assess induced-Mesenchymal Stromal Cell secretome in mixed-culture disease models
por: Burgess, Jeremy D., et al.
Publicado: (2023)

A mutant methionyl-tRNA synthetase-based toolkit to assess induced-mesenchymal stromal cell secretome in mixed-culture disease models
por: Burgess, Jeremy D., et al.
Publicado: (2023)

Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance
por: Cook, Casey, et al.
Publicado: (2014)

Lysosomal polygenic risk is associated with the severity of neuropathology in Lewy body disease
por: Tunold, Jon-Anders, et al.
Publicado: (2023)

Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice
por: Hu, Jin, et al.
Publicado: (2015)

Associations between APOE polymorphisms and seven diseases with cognitive impairment including Alzheimer’s disease, frontotemporal dementia, and dementia with Lewy bodies in southeast China
por: Chen, Ke-Liang, et al.
Publicado: (2016)

APOE-ε4 and BIN1 increase risk of Alzheimer’s disease pathology but not specifically of Lewy body pathology
por: Talyansky, Seth, et al.
Publicado: (2023)

APOE-ε4 and BIN1 increase risk of Alzheimer’s disease pathology but not specifically of Lewy body pathology
por: Talyansky, Seth, et al.
Publicado: (2023)

Generation and validation of APOE knockout human iPSC-derived cerebral organoids
por: Martens, Yuka A., et al.
Publicado: (2021)

Features of Lipid Metabolism in Humanized ApoE Knockin Rat Models
por: Wu, Yang, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_jdleml3uu04tghd1lepat1703t