Attenuation of Excess TNF-α Release in Crohn’s Disease by Silencing of iRHOMs 1/2 and the Restoration of TGF-β Mediated Immunosuppression Through Modulation of TACE Trafficking

TNFα converting enzyme (TACE) is a transmembrane metalloprotease that sheds an assortment of signaling receptors, cytokines, growth factors, and pro-inflammatory mediators. In Crohn’s disease (CD), TACE activity is upregulated, resulting in a marked increase of TNFα secretion and inflammation. Altho...

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Detalles Bibliográficos
Autores principales: Louis, Taylor J., Qasem, Ahmad, Naser, Saleh A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108260/
https://www.ncbi.nlm.nih.gov/pubmed/35585977
http://dx.doi.org/10.3389/fimmu.2022.887830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108260/
https://www.ncbi.nlm.nih.gov/pubmed/35585977
http://dx.doi.org/10.3389/fimmu.2022.887830

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