The Bradycardic Agent Ivabradine Acts as an Atypical Inhibitor of Voltage-Gated Sodium Channels

Background and purpose: Ivabradine is clinically administered to lower the heart rate, proposedly by inhibiting hyperpolarization-activated cyclic nucleotide-gated cation channels in the sinoatrial node. Recent evidence suggests that voltage-gated sodium channels (VGSC) are inhibited within the same...

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Detalles Bibliográficos
Autores principales: Hackl, Benjamin, Lukacs, Peter, Ebner, Janine, Pesti, Krisztina, Haechl, Nicholas, Földi, Mátyás C, Lilliu, Elena, Schicker, Klaus, Kubista, Helmut, Stary-Weinzinger, Anna, Hilber, Karlheinz, Mike, Arpad, Todt, Hannes, Koenig, Xaver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108390/
https://www.ncbi.nlm.nih.gov/pubmed/35586063
http://dx.doi.org/10.3389/fphar.2022.809802

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108390/
https://www.ncbi.nlm.nih.gov/pubmed/35586063
http://dx.doi.org/10.3389/fphar.2022.809802

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