Cargando…

Estrogen Metabolite 2-Methoxyestradiol Attenuates Blood Pressure in Hypertensive Rats by Downregulating Angiotensin Type 1 Receptor

The therapeutic potential of 2-Methoxyestradiol (2ME2) is evident in cardiovascular disease. Our laboratory has previously demonstrated the mechanism involved in the 2ME2 regulation of angiotensin type 1 receptor (AT1R) in vitro. However, 2ME2 regulation of angiotensin receptors and its effects on b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yong, Ogola, Benard O., Iyer, Laxmi, Karamyan, Vardan T., Thekkumkara, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108484/ https://www.ncbi.nlm.nih.gov/pubmed/35586713 http://dx.doi.org/10.3389/fphys.2022.876777

Ejemplares similares

Overexpression of ß-Arrestin1 in the Rostral Ventrolateral Medulla Downregulates Angiotensin Receptor and Lowers Blood Pressure in Hypertension
por: Sun, Jia-Cen, et al.
Publicado: (2018)

Angiotensin II type 1 receptor antagonists in the treatment of hypertension in elderly patients: focus on patient outcomes
por: Tadevosyan, Artavazd, et al.
Publicado: (2011)

Macrophage Depletion Lowered Blood Pressure and Attenuated Hypertensive Renal Injury and Fibrosis
por: Huang, Lei, et al.
Publicado: (2018)

Enzymatic pathways of the brain renin–angiotensin system: Unsolved problems and continuing challenges
por: Karamyan, Vardan T., et al.
Publicado: (2007)

G Protein-Coupled Estrogen Receptor Protects From Angiotensin II-Induced Increases in Pulse Pressure and Oxidative Stress
por: Ogola, Benard O., et al.
Publicado: (2019)

Chronic Intermittent Hypobaric Hypoxia Decreases High Blood Pressure by Stabilizing the Vascular Renin-Angiotensin System in Spontaneously Hypertensive Rats
por: Chen, Hua, et al.
Publicado: (2021)

Distribution of a novel binding site for angiotensins II and III in mouse tissues
por: Rabey, Felicia M., et al.
Publicado: (2010)

Role of Mineralocorticoid and Angiotensin Type 1 Receptors in the Paraventricular Nucleus in Angiotensin-Induced Hypertension
por: Burke, Sandra L., et al.
Publicado: (2021)

2-Methoxyestradiol Ameliorates Angiotensin II–Induced Hypertension by Inhibiting Cytosolic Phospholipase A(2)α Activity in Female Mice
por: Song, Chi Young, et al.
Publicado: (2021)

2-Methoxyestradiol as an Antiproliferative Agent for Long-Term Estrogen-Deprived Breast Cancer Cells
por: Hirao-Suzuki, Masayo, et al.
Publicado: (2023)

The Bone Sparing Effects of 2-Methoxyestradiol Are Mediated via Estrogen Receptor-α in Male Mice
por: Eriksson, Anna L., et al.
Publicado: (2016)

Increased Respiratory Modulation of Blood Pressure in Hypertensive Patients
por: Xie, Lin, et al.
Publicado: (2019)

Brain Renin–Angiotensin System in Hypertension, Cardiac Hypertrophy, and Heart Failure
por: Campos, Luciana Aparecida, et al.
Publicado: (2012)

Inhibition of salty taste and sodium appetite by estrogens in spontaneously hypertensive rats
por: Pereira, Emilson Donizete, et al.
Publicado: (2023)

The estrogen metabolite 2-methoxyestradiol regulates eukaryotic initiation factor 4E (eIF4E) and inhibits protein synthesis in MG63 osteosarcoma cells
por: Maran, Avudaiappan, et al.
Publicado: (2016)

Inappropriate activation of the renin-angiotensin system improves cardiac tolerance to ischemia/reperfusion injury in rats with late angiotensin II-dependent hypertension
por: Husková, Zuzana, et al.
Publicado: (2023)

2-Methoxyestradiol protects against pressure overload-induced left ventricular hypertrophy
por: Maayah, Zaid H., et al.
Publicado: (2018)

The Selective Angiotensin II Type 2 Receptor Agonist, Compound 21, Attenuates the Progression of Lung Fibrosis and Pulmonary Hypertension in an Experimental Model of Bleomycin-Induced Lung Injury
por: Rathinasabapathy, Anandharajan, et al.
Publicado: (2018)

Effects of exercise modalities on decreased blood pressure in patients with hypertension
por: Ramis, Thiago Rozales, et al.
Publicado: (2022)

Circadian Differences in the Contribution of the Brain Renin-Angiotensin System in Genetically Hypertensive Mice
por: Jackson, Kristy L., et al.
Publicado: (2018)

Heart Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 Gene Expression Associated With Male Sex and Salt-Sensitive Hypertension in the Dahl Rat
por: Ytrehus, Kirsti, et al.
Publicado: (2021)

The Angiotensin II Type 1 Receptor-Associated Protein Attenuates Angiotensin II-Mediated Inhibition of the Renal Outer Medullary Potassium Channel in Collecting Duct Cells
por: Polidoro, Juliano Zequini, et al.
Publicado: (2021)

Blockade of Rostral Ventrolateral Medulla Apelin Receptors Does Not Attenuate Arterial Pressure in SHR and (L)-NAME-Induced Hypertensive Rats
por: Griffiths, Philip R., et al.
Publicado: (2018)

Role of monocytes/macrophages in renin-angiotensin system-induced hypertension and end organ damage
por: Barhoumi, Tlili, et al.
Publicado: (2023)

Regulation of human salt-sensitivite hypertension by myeloid cell renin-angiotensin-aldosterone system
por: Ertuglu, Lale A., et al.
Publicado: (2023)

Country of birth affects blood pressure in the French hypertensive diabetic population
por: Aoun Bahous, Sola, et al.
Publicado: (2015)

Angiotensin II and the Renal Hemodynamic Response to an Isolated Increased Renal Venous Pressure in Rats
por: Huang, Xiaohua, et al.
Publicado: (2021)

How Perturbated Metabolites in Diabetes Mellitus Affect the Pathogenesis of Hypertension?
por: Ning, Zhangchi, et al.
Publicado: (2021)

Angiotensin-II-derived reactive oxygen species on baroreflex sensitivity during hypertension: new perspectives
por: de Queiroz, Thyago M., et al.
Publicado: (2013)

Renal Denervation Promotes Atherosclerosis in Hypertensive Apolipoprotein E-Deficient Mice Infused with Angiotensin II
por: Wang, Yutang, et al.
Publicado: (2017)

Restoring Blood Pressure in Hypertensive Mice Fails to Fully Reverse Vascular Stiffness
por: Steppan, Jochen, et al.
Publicado: (2020)

Sex Differences in the Vasodilation Mediated by G Protein-Coupled Estrogen Receptor (GPER) in Hypertensive Rats
por: Delgado, Nathalie Tristão Banhos, et al.
Publicado: (2021)

The role of peptidase neurolysin in neuroprotection and neural repair after stroke
por: Karamyan, Vardan T.
Publicado: (2020)

Between two storms, vasoactive peptides or bradykinin underlie severity of COVID‐19?
por: Karamyan, Vardan T.
Publicado: (2021)

Angiotensin-(1-7) Inhibits Thrombin-Induced Endothelial Phenotypic Changes and Reactive Oxygen Species Production via NADPH Oxidase 5 Downregulation
por: Pai, Wan-Yu, et al.
Publicado: (2017)

Intratubular, Intracellular, and Mitochondrial Angiotensin II/AT(1) (AT1a) Receptor/NHE3 Signaling Plays a Critical Role in Angiotensin II-Induced Hypertension and Kidney Injury
por: Li, Xiao Chun, et al.
Publicado: (2021)

Renin-Angiotensin System Responds to Prolonged Hypotensive Effect Induced by Mandibular Extension in Spontaneously Hypertensive Rats
por: Sabatino, Laura, et al.
Publicado: (2018)

Transcriptome Analysis Reveals Downregulation of Urocortin Expression in the Hypothalamo-Neurohypophysial System of Spontaneously Hypertensive Rats
por: Martin, Andrew, et al.
Publicado: (2021)

Effect of Maternal Obstructive Sleep Apnea-Hypopnea on 24-Hour Blood Pressure, Nocturnal Blood Pressure Dipping and Arterial Stiffness in Hypertensive Disorders of Pregnancy
por: Panyarath, Pattaraporn, et al.
Publicado: (2021)

Effects of Renal Denervation on Sympathetic Activation, Blood Pressure, and Glucose Metabolism in Patients with Resistant Hypertension
por: Schlaich, Markus P., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_4d9risrs06qksg9ut85lr4r1kh