Human UPF3A and UPF3B enable fault‐tolerant activation of nonsense‐mediated mRNA decay

The paralogous human proteins UPF3A and UPF3B are involved in recognizing mRNAs targeted by nonsense‐mediated mRNA decay (NMD). UPF3B has been demonstrated to support NMD, presumably by bridging an exon junction complex (EJC) to the NMD factor UPF2. The role of UPF3A has been described either as a w...

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Detalles Bibliográficos
Autores principales: Wallmeroth, Damaris, Lackmann, Jan‐Wilm, Kueckelmann, Sabrina, Altmüller, Janine, Dieterich, Christoph, Boehm, Volker, Gehring, Niels H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108619/
https://www.ncbi.nlm.nih.gov/pubmed/35451084
http://dx.doi.org/10.15252/embj.2021109191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108619/
https://www.ncbi.nlm.nih.gov/pubmed/35451084
http://dx.doi.org/10.15252/embj.2021109191

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