Tumor Derived Extracellular Vesicles Drive T Cell Exhaustion in Tumor Microenvironment through Sphingosine Mediated Signaling and Impacting Immunotherapy Outcomes in Ovarian Cancer

SPHK1 (sphingosine kinase‐1) catalyzes the phosphorylation of sphingosine to sphingosine‐1‐phosphate (S1P), is found to be highly expressed in solid tumors. Here, extracellular vesicles (EVs) are identified as the key transporters of SPHK1 to the tumor microenvironment. Consequently, SPHK1‐packaged...

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Detalles Bibliográficos
Autores principales: Gupta, Prachi, Kadamberi, Ishaque Pulikkal, Mittal, Sonam, Tsaih, Shirng‐Wern, George, Jasmine, Kumar, Sudhir, Vijayan, Dileep K., Geethadevi, Anjali, Parashar, Deepak, Topchyan, Paytsar, McAlarnen, Lindsey, Volkman, Brian F, Cui, Weiguo, Zhang, Kam Y. J., Di Vizio, Dolores, Chaluvally‐Raghavan, Pradeep, Pradeep, Sunila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108620/
https://www.ncbi.nlm.nih.gov/pubmed/35289120
http://dx.doi.org/10.1002/advs.202104452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108620/
https://www.ncbi.nlm.nih.gov/pubmed/35289120
http://dx.doi.org/10.1002/advs.202104452

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