Cargando…

Tumor Derived Extracellular Vesicles Drive T Cell Exhaustion in Tumor Microenvironment through Sphingosine Mediated Signaling and Impacting Immunotherapy Outcomes in Ovarian Cancer

SPHK1 (sphingosine kinase‐1) catalyzes the phosphorylation of sphingosine to sphingosine‐1‐phosphate (S1P), is found to be highly expressed in solid tumors. Here, extracellular vesicles (EVs) are identified as the key transporters of SPHK1 to the tumor microenvironment. Consequently, SPHK1‐packaged...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gupta, Prachi, Kadamberi, Ishaque Pulikkal, Mittal, Sonam, Tsaih, Shirng‐Wern, George, Jasmine, Kumar, Sudhir, Vijayan, Dileep K., Geethadevi, Anjali, Parashar, Deepak, Topchyan, Paytsar, McAlarnen, Lindsey, Volkman, Brian F, Cui, Weiguo, Zhang, Kam Y. J., Di Vizio, Dolores, Chaluvally‐Raghavan, Pradeep, Pradeep, Sunila
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108620/ https://www.ncbi.nlm.nih.gov/pubmed/35289120 http://dx.doi.org/10.1002/advs.202104452

Ejemplares similares

Preclinical activity of selinexor in combination with eribulin in uterine leiomyosarcoma
por: Mittal, Sonam, et al.
Publicado: (2023)

Extracellular vesicle contents as non-invasive biomarkers in ovarian malignancies
por: McAlarnen, Lindsey A., et al.
Publicado: (2022)

Optimized proximity ligation assay (PLA) for detection of RNA-protein complex interactions in cell lines
por: George, Jasmine, et al.
Publicado: (2022)

Patient-Derived Ovarian Cancer Spheroids Rely on PI3K-AKT Signaling Addiction for Cancer Stemness and Chemoresistance
por: Parashar, Deepak, et al.
Publicado: (2022)

Correction: Parashar et al. Patient-Derived Ovarian Cancer Spheroids Rely on PI3K-AKT Signaling Addiction for Cancer Stemness and Chemoresistance. Cancers 2022, 14, 958
por: Parashar, Deepak, et al.
Publicado: (2022)

ERBB3-induced furin promotes the progression and metastasis of ovarian cancer via the IGF1R/STAT3 signaling axis
por: Chen, Changliang, et al.
Publicado: (2020)

RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site
por: George, Jasmine, et al.
Publicado: (2021)

Metabolic Reprogramming in Tumor-Associated Macrophages in the Ovarian Tumor Microenvironment
por: Kumar, Sudhir, et al.
Publicado: (2022)

Emerging Role of Extracellular Vesicles in Immune Regulation and Cancer Progression
por: Mittal, Sonam, et al.
Publicado: (2020)

Virtual visits among gynecologic oncology patients during the COVID-19 pandemic are accessible across the social vulnerability spectrum
por: McAlarnen, Lindsey A., et al.
Publicado: (2021)

ERBB signaling in CTCs of ovarian cancer and glioblastoma
por: Geethadevi, Anjali, et al.
Publicado: (2017)

B Cells as an Immune-Regulatory Signature in Ovarian Cancer
por: Gupta, Prachi, et al.
Publicado: (2019)

Targeted biologic inhibition of both tumor cell-intrinsic and intercellular CLPTM1L/CRR9-mediated chemotherapeutic drug resistance
por: Parashar, Deepak, et al.
Publicado: (2021)

Fluorinated triphenylphosphonium analogs improve cell selectivity and in vivo detection of mito-metformin
por: AbuEid, Mahmoud, et al.
Publicado: (2022)

Racial differences in attitudes toward COVID-19 vaccination during pregnancy
por: Binger, Kole S., et al.
Publicado: (2022)

Factors of COVID-19 vaccine hesitancy during pregnancy: a cross-sectional study
por: Cui, Yiwen, et al.
Publicado: (2022)

Factors associated with receipt of COVID-19 immunization during pregnancy
por: Binger, Kole S., et al.
Publicado: (2022)

Understanding COVID-19 vaccine hesitancy in pregnant patients
por: Cui, Yiwen, et al.
Publicado: (2022)

Targeting ncRNAs in the 3q26.2 amplicon
por: Chaluvally-Raghavan, Pradeep, et al.
Publicado: (2015)

Challenges of Genomic Testing for Hereditary Breast and Ovarian Cancers
por: McAlarnen, Lindsey, et al.
Publicado: (2021)

Determinants of Bone and Blood Lead Levels among Minorities Living in the Boston Area
por: Lin, Charles, et al.
Publicado: (2004)

The medical transition of young adults with type 1 diabetes (T1D): a retrospective chart review identifies areas in need of improvement
por: Walch, Abby M., et al.
Publicado: (2020)

NNAT is a novel mediator of oxidative stress that suppresses ER + breast cancer
por: Plasterer, Cody, et al.
Publicado: (2023)

Identification of a Rat Mammary Tumor Risk Locus That Is Syntenic with the Commonly Amplified 8q12.1 and 8q22.1 Regions in Human Breast Cancer Patients
por: Plasterer, Cody, et al.
Publicado: (2019)

Cigarette smoke downregulates Nur77 to exacerbate inflammation in chronic obstructive pulmonary disease (COPD)
por: Reddy, Aravind T., et al.
Publicado: (2020)

Internet and Free Press Are Associated with Reduced Lags in Global Outbreak Reporting
por: McAlarnen, Lindsey, et al.
Publicado: (2014)

A case series of triplet anti-hormonal therapy in androgen receptor-positive recurrent adult ovarian granulosa cell tumor()
por: Summey, Rebekah M., et al.
Publicado: (2022)

The Role of CD4 T Cell Help in CD8 T Cell Differentiation and Function During Chronic Infection and Cancer
por: Topchyan, Paytsar, et al.
Publicado: (2023)

Genetic control of murine invariant natural killer T-cells maps to multiple type 1 diabetes regions
por: Tsaih, Shirng-Wern, et al.
Publicado: (2013)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

Augmented IFN-γ and TNF-α Induced by Probiotic Bacteria in NK Cells Mediate Differentiation of Stem-Like Tumors Leading to Inhibition of Tumor Growth and Reduction in Inflammatory Cytokine Release; Regulation by IL-10
por: Bui, Vickie T., et al.
Publicado: (2015)

Lead, Diabetes, Hypertension, and Renal Function: The Normative Aging Study
por: Tsaih, Shirng-Wern, et al.
Publicado: (2004)

A High-Resolution Genetic Map for the Laboratory Rat
por: Littrell, John, et al.
Publicado: (2018)

Differentiation by NK cells is a prerequisite for effective targeting of cancer stem cells/poorly differentiated tumors by chemopreventive and chemotherapeutic drugs
por: Kozlowska, Anna Karolina, et al.
Publicado: (2017)

A locus on mouse Chromosome 13 inversely regulates CD1d expression and the development of invariant natural killer T-cells
por: Tsaih, Shirng-Wern, et al.
Publicado: (2015)

Interaction of tumor cells and astrocytes promotes breast cancer brain metastases through TGF-β2/ANGPTL4 axes
por: Gong, Xianghui, et al.
Publicado: (2019)

A recombinant decoy comprising EGFR and ErbB-4 inhibits tumor growth and metastasis
por: Lindzen, Moshit, et al.
Publicado: (2011)

Idd9/11 Genetic Locus Regulates Diabetogenic Activity of CD4 T-Cells in Nonobese Diabetic (NOD) Mice
por: Chen, Yi-Guang, et al.
Publicado: (2008)

Structural Model Analysis of Multiple Quantitative Traits
por: Li, Renhua, et al.
Publicado: (2006)

An experimental assessment of in silico haplotype association mapping in laboratory mice
por: Burgess-Herbert, Sarah L, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_8fapgi4aa2rcj9g4sh0dtphvkt