Mammalian UPF3A and UPF3B can activate nonsense‐mediated mRNA decay independently of their exon junction complex binding

Nonsense‐mediated mRNA decay (NMD) is governed by the three conserved factors—UPF1, UPF2, and UPF3. While all three are required for NMD in yeast, UPF3B is dispensable for NMD in mammals, and its paralog UPF3A is suggested to only weakly activate or even repress NMD due to its weaker binding to the...

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Detalles Bibliográficos
Autores principales: Yi, Zhongxia, Arvola, René M, Myers, Sean, Dilsavor, Corinne N, Abu Alhasan, Rabab, Carter, Bayley N, Patton, Robert D, Bundschuh, Ralf, Singh, Guramrit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108626/
https://www.ncbi.nlm.nih.gov/pubmed/35451102
http://dx.doi.org/10.15252/embj.2021109202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108626/
https://www.ncbi.nlm.nih.gov/pubmed/35451102
http://dx.doi.org/10.15252/embj.2021109202

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