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Mycobacterium tuberculosis impedes CD40-dependent notch signaling to restrict Th(17) polarization during infection

Early Th(17) responses are necessary to provide protection against Mycobacterium tuberculosis (Mtb). Mtb impedes Th(17) polarization by restricting CD40 co-stimulatory pathway on dendritic cells (DCs). We previously demonstrated that engaging CD40 on DCs increased Th(17) responses. However, the mole...

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Detalles Bibliográficos
Autores principales: Enriquez, Ana Beatriz, Sia, Jonathan Kevin, Dkhar, Hedwin Kitdorlang, Goh, Shu Ling, Quezada, Melanie, Stallings, Kristina Larrieux, Rengarajan, Jyothi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108765/
https://www.ncbi.nlm.nih.gov/pubmed/35586066
http://dx.doi.org/10.1016/j.isci.2022.104305