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The mouse nicotinamide mononucleotide adenylyltransferase chaperones diverse pathological amyloid client proteins
Molecular chaperones safeguard cellular protein homeostasis and obviate proteotoxicity. In the process of aging, as chaperone networks decline, aberrant protein amyloid aggregation accumulates in a mechanism that underpins neurodegeneration, leading to pathologies such as Alzheimer’s disease and Par...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108885/ https://www.ncbi.nlm.nih.gov/pubmed/35398355 http://dx.doi.org/10.1016/j.jbc.2022.101912 |