Bioinformatic identification of previously unrecognized amyloidogenic proteins

Low-complexity domains (LCDs) of proteins have been shown to self-associate, and pathogenic mutations within these domains often drive the proteins into amyloid aggregation associated with disease. These domains may be especially susceptible to amyloidogenic mutations because they are commonly intri...

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Detalles Bibliográficos
Autores principales: Rosenberg, Gregory M., Murray, Kevin A., Salwinski, Lukasz, Hughes, Michael P., Abskharon, Romany, Eisenberg, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108986/
https://www.ncbi.nlm.nih.gov/pubmed/35405097
http://dx.doi.org/10.1016/j.jbc.2022.101920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108986/
https://www.ncbi.nlm.nih.gov/pubmed/35405097
http://dx.doi.org/10.1016/j.jbc.2022.101920

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