Metabolic flux analysis of 3D spheroids reveals significant differences in glucose metabolism from matched 2D cultures of colorectal cancer and pancreatic ductal adenocarcinoma cell lines

BACKGROUND: Most in vitro cancer cell experiments have been performed using 2D models. However, 3D spheroid cultures are increasingly favored for being more representative of in vivo tumor conditions. To overcome the translational challenges with 2D cell cultures, 3D systems better model more comple...

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Detalles Bibliográficos
Autores principales: Tidwell, Tia R., Røsland, Gro V., Tronstad, Karl Johan, Søreide, Kjetil, Hagland, Hanne R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109327/
https://www.ncbi.nlm.nih.gov/pubmed/35578327
http://dx.doi.org/10.1186/s40170-022-00285-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109327/
https://www.ncbi.nlm.nih.gov/pubmed/35578327
http://dx.doi.org/10.1186/s40170-022-00285-w

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