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Therapeutic targeting of PFKFB3 and PFKFB4 in multiple myeloma cells under hypoxic conditions

The treatment of multiple myeloma (MM) patients has been dramatically changed by the introduction of new agents; however, many patients relapse. Hypoxia is a critical component of the bone-marrow microenvironment. 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB) is responsible for mainta...

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Detalles Bibliográficos
Autores principales:	Okabe, Seiichi, Tanaka, Yuko, Gotoh, Akihiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Letter to the Editor
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109357/ https://www.ncbi.nlm.nih.gov/pubmed/35578370 http://dx.doi.org/10.1186/s40364-022-00376-2

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