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Th1 cytokines synergize to change gene expression and promote corticosteroid insensitivity in pediatric airway smooth muscle
BACKGROUND: Corticosteroids remain a key therapy for treating children with asthma. Patients with severe asthma are insensitive, resistant, or refractory to corticosteroids and have poorly controlled symptoms that involve airway inflammation, airflow obstruction, and frequent exacerbations. While th...
Autores principales: | Jackson, Devine, Walum, Joshua, Banerjee, Priyanka, Lewis, Brandon W., Prakash, Y. S., Sathish, Venkatachalem, Xu, Zhaohui, Britt, Rodney D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109364/ https://www.ncbi.nlm.nih.gov/pubmed/35578269 http://dx.doi.org/10.1186/s12931-022-02046-1 |
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