Preparation, in vitro and in vivo Evaluation of Thermosensitive in situ Gel Loaded with Ibuprofen-Solid Lipid Nanoparticles for Rectal Delivery

BACKGROUND: Ibuprofen (IBU), a nonsteroidal anti-inflammatory drug, shows poor gastrointestinal absorption due to its low solubility, which limits its clinical application. OBJECTIVE: In the present study, we aimed to develop thermosensitive gel-mediated ibuprofen-solid lipid nanoparticles (IBU-SLN-...

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Detalles Bibliográficos
Autores principales: Huang, Chun-hui, Hu, Peng-yi, Wu, Qiu-yan, Xia, Ming-yan, Zhang, Wen-liu, Lei, Zhi-qiang, Li, Dong-xun, Zhang, Guo-song, Feng, Jian-fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109935/
https://www.ncbi.nlm.nih.gov/pubmed/35586185
http://dx.doi.org/10.2147/DDDT.S350886

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109935/
https://www.ncbi.nlm.nih.gov/pubmed/35586185
http://dx.doi.org/10.2147/DDDT.S350886

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