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Preparation, in vitro and in vivo Evaluation of Thermosensitive in situ Gel Loaded with Ibuprofen-Solid Lipid Nanoparticles for Rectal Delivery

BACKGROUND: Ibuprofen (IBU), a nonsteroidal anti-inflammatory drug, shows poor gastrointestinal absorption due to its low solubility, which limits its clinical application. OBJECTIVE: In the present study, we aimed to develop thermosensitive gel-mediated ibuprofen-solid lipid nanoparticles (IBU-SLN-...

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Detalles Bibliográficos
Autores principales:	Huang, Chun-hui, Hu, Peng-yi, Wu, Qiu-yan, Xia, Ming-yan, Zhang, Wen-liu, Lei, Zhi-qiang, Li, Dong-xun, Zhang, Guo-song, Feng, Jian-fang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109935/ https://www.ncbi.nlm.nih.gov/pubmed/35586185 http://dx.doi.org/10.2147/DDDT.S350886

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