In vitro characterization of the furin inhibitor MI-1851: Albumin binding, interaction with cytochrome P450 enzymes and cytotoxicity

The substrate-analog furin inhibitor MI-1851 can suppress the cleavage of SARS-CoV-2 spike protein and consequently produces significant antiviral effect on infected human airway epithelial cells. In this study, the interaction of inhibitor MI-1851 was examined with human serum albumin using fluores...

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Detalles Bibliográficos
Autores principales: Pászti-Gere, Erzsébet, Szentkirályi-Tóth, Anna, Szabó, Pál, Steinmetzer, Torsten, Fliszár-Nyúl, Eszter, Poór, Miklós
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Masson SAS. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110138/
https://www.ncbi.nlm.nih.gov/pubmed/35594709
http://dx.doi.org/10.1016/j.biopha.2022.113124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110138/
https://www.ncbi.nlm.nih.gov/pubmed/35594709
http://dx.doi.org/10.1016/j.biopha.2022.113124

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