Design, Synthesis and Activity Study of Pyridine Derivatives as Highly Effective and Selective TYK2 Inhibitors

Due to the high homology of the ATP sites of the JAK family, the development of selective inhibitors for a certain JAK isoform is extremely challenging. Our strategy to achieve high selectivity for TYK2 relies on targeting the TYK2 pseudokinase (JH2) domain. Based on the clinical compound BMS-986165...

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Detalles Bibliográficos
Autores principales: Cheng, Chaoying, Zhou, Mengguang, Zhang, Panpan, Qian, Wenjian, Chen, Lei, Chen, Guorong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110192/
https://www.ncbi.nlm.nih.gov/pubmed/35586808
http://dx.doi.org/10.1155/2022/6383893

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110192/
https://www.ncbi.nlm.nih.gov/pubmed/35586808
http://dx.doi.org/10.1155/2022/6383893

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