rVSV-ΔG-SARS-CoV-2-S vaccine: repeated intramuscular (IM) toxicity, local tolerance, immunogenicity and biodistribution study in NZW rabbits

BriLife(®), a vector-based vaccine that utilizes the recombinant vesicular stomatitis virus (VSV) platform to express and present the spike antigen of SARS-CoV-2, is undergoing testing in a phase 2 clinical trial in Israel. A nonclinical repeated-dose (GLP) toxicity study in New Zealand white rabbit...

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Detalles Bibliográficos
Autores principales: Rosner, Amir, Steiner, Michal, Melamed, Sharon, Politi, Boaz, Vitner, Einat, Tamir, Hadas, Achdout, Hagit, Cherry, Lilach, Avraham, Roy, Yahalom-Ronen, Yfat, Levy, Haim, Beth-Din, Adi, Stein, Dana, Mechaly, Adva, Fisher, Morly, Fatelevich, Ella, Weiss, Shay, Kronfeld, Noam, Madar-Shapiro, Liora, Nyska, Abraham, Yitzhaki, Shmuel, Paran, Nir, Israely, Tomer, Marcus, Hadar, Madar-Balakirski, Noa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Immunotoxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110212/
https://www.ncbi.nlm.nih.gov/pubmed/35577986
http://dx.doi.org/10.1007/s00204-022-03302-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110212/
https://www.ncbi.nlm.nih.gov/pubmed/35577986
http://dx.doi.org/10.1007/s00204-022-03302-5

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