Fluctuating methylation clocks for cell lineage tracing at high temporal resolution in human tissues

Molecular clocks that record cell ancestry mutate too slowly to measure the short-timescale dynamics of cell renewal in adult tissues. Here, we show that fluctuating DNA methylation marks can be used as clocks in cells where ongoing methylation and demethylation cause repeated ‘flip–flops’ between m...

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Detalles Bibliográficos
Autores principales: Gabbutt, Calum, Schenck, Ryan O., Weisenberger, Daniel J., Kimberley, Christopher, Berner, Alison, Househam, Jacob, Lakatos, Eszter, Robertson-Tessi, Mark, Martin, Isabel, Patel, Roshani, Clark, Susan K., Latchford, Andrew, Barnes, Chris P., Leedham, Simon J., Anderson, Alexander R. A., Graham, Trevor A., Shibata, Darryl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110299/
https://www.ncbi.nlm.nih.gov/pubmed/34980912
http://dx.doi.org/10.1038/s41587-021-01109-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110299/
https://www.ncbi.nlm.nih.gov/pubmed/34980912
http://dx.doi.org/10.1038/s41587-021-01109-w

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