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Doxorubicin impacts chromatin binding of HMGB1, Histone H1 and retinoic acid receptor
Doxorubicin (Dox), a widely used anticancer DNA-binding drug, affects chromatin in multiple ways, and these effects contribute to both its efficacy and its dose-limiting side effects, especially cardiotoxicity. Here, we studied the effects of Dox on the chromatin binding of the architectural protein...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110345/ https://www.ncbi.nlm.nih.gov/pubmed/35577872 http://dx.doi.org/10.1038/s41598-022-11994-z |