Doxorubicin impacts chromatin binding of HMGB1, Histone H1 and retinoic acid receptor

Doxorubicin (Dox), a widely used anticancer DNA-binding drug, affects chromatin in multiple ways, and these effects contribute to both its efficacy and its dose-limiting side effects, especially cardiotoxicity. Here, we studied the effects of Dox on the chromatin binding of the architectural protein...

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Detalles Bibliográficos
Autores principales: Bosire, Rosevalentine, Fadel, Lina, Mocsár, Gábor, Nánási, Péter, Sen, Pialy, Sharma, Anshu Kumar, Naseem, Muhammad Umair, Kovács, Attila, Kugel, Jennifer, Kroemer, Guido, Vámosi, György, Szabó, Gábor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110345/
https://www.ncbi.nlm.nih.gov/pubmed/35577872
http://dx.doi.org/10.1038/s41598-022-11994-z

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