Mitochondrial TrxR2 regulates metabolism and protects from metabolic disease through enhanced TCA and ETC function

Mitochondrial dysfunction is a key driver of diabetes and other metabolic diseases. Mitochondrial redox state is highly impactful to metabolic function but the mechanism driving this is unclear. We generated a transgenic mouse which overexpressed the redox enzyme Thioredoxin Reductase 2 (TrxR2), the...

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Detalles Bibliográficos
Autores principales: Chocron, E. Sandra, Mdaki, Kennedy, Jiang, Nisi, Cropper, Jodie, Pickering, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110405/
https://www.ncbi.nlm.nih.gov/pubmed/35577894
http://dx.doi.org/10.1038/s42003-022-03405-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110405/
https://www.ncbi.nlm.nih.gov/pubmed/35577894
http://dx.doi.org/10.1038/s42003-022-03405-w

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