IGF-1 release in the medial prefrontal cortex mediates the rapid and sustained antidepressant-like actions of ketamine

Ketamine, an N-methyl-D-aspartate receptor antagonist, exerts rapid and sustained antidepressant actions. Preclinical studies demonstrated that the release of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor in the medial prefrontal cortex (mPFC) is essential for the a...

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Detalles Bibliográficos
Autores principales: Deyama, Satoshi, Kondo, Makoto, Shimada, Shoichi, Kaneda, Katsuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110717/
https://www.ncbi.nlm.nih.gov/pubmed/35577782
http://dx.doi.org/10.1038/s41398-022-01943-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110717/
https://www.ncbi.nlm.nih.gov/pubmed/35577782
http://dx.doi.org/10.1038/s41398-022-01943-9

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