Structure-Based Design of 2-Aminopurine Derivatives as CDK2 Inhibitors for Triple-Negative Breast Cancer

Cyclin-dependent kinase 2 (CDK2) regulates the progression of the cell cycle and is critically associated with tumor growth. Selective CDK2 inhibition provides a potential therapeutic benefit against certain tumors. Purines and related heterocycle (e.g., R-Roscovitine) are important scaffolds in the...

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Detalles Bibliográficos
Autores principales: Liang, Hanzhi, Zhu, Yue, Zhao, Zhiyuan, Du, Jintong, Yang, Xinying, Fang, Hao, Hou, Xuben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110766/
https://www.ncbi.nlm.nih.gov/pubmed/35592410
http://dx.doi.org/10.3389/fphar.2022.864342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110766/
https://www.ncbi.nlm.nih.gov/pubmed/35592410
http://dx.doi.org/10.3389/fphar.2022.864342

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