Structural bioinformatics enhances the interpretation of somatic mutations in KDM6A found in human cancers

The histone demethylase KDM6A has recently elicited significant attention because its mutations are associated with a rare congenital disorder (Kabuki syndrome) and various types of human cancers. However, distinguishing KDM6A mutations that are deleterious to the enzyme and their underlying mechani...

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Detalles Bibliográficos
Autores principales: Chi, Young-In, Stodola, Timothy J., De Assuncao, Thiago M., Leverence, Elise N., Smith, Brian C., Volkman, Brian F., Mathison, Angela J., Lomberk, Gwen, Zimmermann, Michael T., Urrutia, Raul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9111933/
https://www.ncbi.nlm.nih.gov/pubmed/35615018
http://dx.doi.org/10.1016/j.csbj.2022.04.028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9111933/
https://www.ncbi.nlm.nih.gov/pubmed/35615018
http://dx.doi.org/10.1016/j.csbj.2022.04.028

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