Chemistry of polyhalogenated nitrobutadienes, 17: Efficient synthesis of persubstituted chloroquinolinyl-1H-pyrazoles and evaluation of their antimalarial, anti-SARS-CoV-2, antibacterial, and cytotoxic activities

A series of 26 novel 1-(7-chloroquinolin-4-yl)-4-nitro-1H-pyrazoles bearing a dichloromethyl and an amino or thio moiety at C3 and C5 has been prepared in yields up to 72% from the reaction of 1,1-bisazolyl-, 1-azolyl-1-amino-, and 1-thioperchloro-2-nitrobuta-1,3-dienes with 7-chloro-4-hydrazinylqui...

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Detalles Bibliográficos
Autores principales: Zapol’skii, Viktor A, Berneburg, Isabell, Bilitewski, Ursula, Dillenberger, Melissa, Becker, Katja, Jungwirth, Stefan, Shekhar, Aditya, Krueger, Bastian, Kaufmann, Dieter E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2022
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112185/
https://www.ncbi.nlm.nih.gov/pubmed/35615535
http://dx.doi.org/10.3762/bjoc.18.54

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112185/
https://www.ncbi.nlm.nih.gov/pubmed/35615535
http://dx.doi.org/10.3762/bjoc.18.54

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