Environmentally Responsible and Cost-Effective Synthesis of the Antimalarial Drug Pyronaridine

[Image: see text] Two routes to the antimalarial drug Pyronaridine are described. The first is a linear sequence that includes a two-step, one-pot transformation in an aqueous surfactant medium, leading to an overall yield of 87%. Alternatively, a convergent route utilizes a telescoped three-step se...

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Detalles Bibliográficos
Autores principales: Kincaid, Joseph R. A., Kavthe, Rahul D., Caravez, Juan C., Takale, Balaram S., Thakore, Ruchita R., Lipshutz, Bruce H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112334/
https://www.ncbi.nlm.nih.gov/pubmed/35504038
http://dx.doi.org/10.1021/acs.orglett.2c00944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112334/
https://www.ncbi.nlm.nih.gov/pubmed/35504038
http://dx.doi.org/10.1021/acs.orglett.2c00944

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