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The crystal structure of TRPM2 MHR1/2 domain reveals a conserved Zn(2+)‐binding domain essential for structural integrity and channel activity
Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)‐permeable, nonselective cation channel involved in diverse physiological processes such as immune response, apoptosis, and body temperature sensing. TRPM2 is activated by ADP‐ribose (ADPR) and 2′‐deoxy‐ADPR in a Ca(2+)‐dependent manner. W...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons, Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112350/ https://www.ncbi.nlm.nih.gov/pubmed/35634784 http://dx.doi.org/10.1002/pro.4320 |