Discovery of pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives as novel CDK2 inhibitors: synthesis, biological and molecular modeling investigations

CDK2 inhibition is an appealing target for cancer treatment that targets tumor cells in a selective manner. A new set of small molecules featuring the privileged pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffolds (4–13) as well as the thioglycoside derivatives (1...

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Detalles Bibliográficos
Autores principales: Nassar, Ibrahim F., Abdel Aal, Mohammed T., El-Sayed, Wael A., A. E Shahin, Mahmoud, Elsakka, Elsayed G. E., Mokhtar, Mahmoud Mohamed, Hegazy, Maghawry, Hagras, Mohamed, Mandour, Asmaa A., Ismail, Nasser S. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112407/
https://www.ncbi.nlm.nih.gov/pubmed/35702208
http://dx.doi.org/10.1039/d2ra01968j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112407/
https://www.ncbi.nlm.nih.gov/pubmed/35702208
http://dx.doi.org/10.1039/d2ra01968j

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