Scaffold stability and P14′ residue steric hindrance in the differential inhibition of FXIIa by Aedes aegypti trypsin inhibitor versus Infestin-4

Kazal-type protease inhibitors strictly regulate Factor XIIa (FXIIa), a blood-clotting serine protease. However, when negatively charged surface of prosthetic device come into contact with FXII, it undergoes conformational change and auto-activation, leading to thrombus formation. Some research sugg...

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Detalles Bibliográficos
Autores principales: Walvekar, Varsha Ashok, Ramesh, Karthik, Kannan, Muthu, Kini, R. Manjunatha, Sivaraman, J., Mok, Yu Keung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Enzymology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112662/
https://www.ncbi.nlm.nih.gov/pubmed/35485437
http://dx.doi.org/10.1042/BSR20220421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112662/
https://www.ncbi.nlm.nih.gov/pubmed/35485437
http://dx.doi.org/10.1042/BSR20220421

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