Selective Inhibition of Plasmodium falciparum ATPase 6 by Artemisinins and Identification of New Classes of Inhibitors after Expression in Yeast

Treatment failures with artemisinin combination therapies (ACTs) threaten global efforts to eradicate malaria. They highlight the importance of identifying drug targets and new inhibitors and of studying how existing antimalarial classes work. Here, we report the successful development of a heterolo...

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Detalles Bibliográficos
Autores principales: Moore, Catherine M., Wang, Jigang, Lin, Qingsong, Ferreira, Pedro, Avery, Mitchell A., Elokely, Khaled, Staines, Henry M., Krishna, Sanjeev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Mechanisms of Action: Physiological Effects
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112895/
https://www.ncbi.nlm.nih.gov/pubmed/35465707
http://dx.doi.org/10.1128/aac.02079-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112895/
https://www.ncbi.nlm.nih.gov/pubmed/35465707
http://dx.doi.org/10.1128/aac.02079-21

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