Engineering sequence and selectivity of late-stage C-H oxidation in the MycG iterative cytochrome P450

MycG is a multifunctional P450 monooxygenase that catalyzes sequential hydroxylation and epoxidation or a single epoxidation in mycinamicin biosynthesis. In the mycinamicin-producing strain Micromonospora griseorubida A11725, very low-level accumulation of mycinamicin V generated by the initial C-14...

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Detalles Bibliográficos
Autores principales: Iizaka, Yohei, Arai, Ryusei, Takahashi, Akari, Ito, Mikino, Sakai, Miho, Fukumoto, Atsushi, Sherman, David H, Anzai, Yojiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Metabolic Engineering and Synthetic Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113108/
https://www.ncbi.nlm.nih.gov/pubmed/34543433
http://dx.doi.org/10.1093/jimb/kuab069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113108/
https://www.ncbi.nlm.nih.gov/pubmed/34543433
http://dx.doi.org/10.1093/jimb/kuab069

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