Development of Fmoc-Protected Bis-Amino Acids toward Automated Synthesis of Highly Functionalized Spiroligomers

[Image: see text] We report the fluorenylmethoxycarbonyl (Fmoc) protection of functionalized bis-amino acid building blocks using a temporary Cu(2+) complexation strategy, together with an efficient multikilogram-scale synthesis of bis-amino acid precursors. This allows the synthesis of stereochemic...

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Detalles Bibliográficos
Autores principales: Xie, Yihui, Luo, Danni, Wiener, Jesse, Tang, Sicheng, Chepyshev, Sergiy, Schafmeister, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113113/
https://www.ncbi.nlm.nih.gov/pubmed/35499925
http://dx.doi.org/10.1021/acs.orglett.2c01295

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113113/
https://www.ncbi.nlm.nih.gov/pubmed/35499925
http://dx.doi.org/10.1021/acs.orglett.2c01295

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