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LGL1 binds to Integrin β1 and inhibits downstream signaling to promote epithelial branching in the mammary gland

Branching morphogenesis is a fundamental process by which organs in invertebrates and vertebrates form branches to expand their surface areas. The current dogma holds that directional cell migration determines where a new branch forms and thus patterns branching. Here, we asked whether mouse Lgl1, a...

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Detalles Bibliográficos
Autores principales: Ma, Rongze, Gong, Difei, You, Huanyang, Xu, Chongshen, Lu, Yunzhe, Bergers, Gabriele, Werb, Zena, Klein, Ophir D., Petritsch, Claudia K., Lu, Pengfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113222/
https://www.ncbi.nlm.nih.gov/pubmed/35172155
http://dx.doi.org/10.1016/j.celrep.2022.110375