8-Azaadenosine and 8-Chloroadenosine are not Selective Inhibitors of ADAR

The RNA editing enzyme ADAR is an attractive therapeutic target for multiple cancers. Through its deaminase activity, ADAR edits adenosine to inosine in double-stranded RNAs. Loss of ADAR in some cancer cell lines causes activation of the type I IFN pathway and the PKR translational repressor, leadi...

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Detalles Bibliográficos
Autores principales: Cottrell, Kyle A., Soto-Torres, Luisangely, Dizon, Michael G., Weber, Jason D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113518/
https://www.ncbi.nlm.nih.gov/pubmed/35586115
http://dx.doi.org/10.1158/2767-9764.CRC-21-0027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113518/
https://www.ncbi.nlm.nih.gov/pubmed/35586115
http://dx.doi.org/10.1158/2767-9764.CRC-21-0027

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