Integrative analysis of scRNA-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator

Medullary thymic epithelial cells (mTECs) are critical for self-tolerance induction in T cells via promiscuous expression of tissue-specific antigens (TSAs), which are controlled by the transcriptional regulator, AIRE. Whereas AIRE-expressing (Aire(+)) mTECs undergo constant turnover in the adult th...

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Detalles Bibliográficos
Autores principales: Miyao, Takahisa, Miyauchi, Maki, Kelly, S Thomas, Terooatea, Tommy W, Ishikawa, Tatsuya, Oh, Eugene, Hirai, Sotaro, Horie, Kenta, Takakura, Yuki, Ohki, Houko, Hayama, Mio, Maruyama, Yuya, Seki, Takao, Ishii, Hiroto, Yabukami, Haruka, Yoshida, Masaki, Inoue, Azusa, Sakaue-Sawano, Asako, Miyawaki, Atsushi, Muratani, Masafumi, Minoda, Aki, Akiyama, Nobuko, Akiyama, Taishin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113748/
https://www.ncbi.nlm.nih.gov/pubmed/35578835
http://dx.doi.org/10.7554/eLife.73998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113748/
https://www.ncbi.nlm.nih.gov/pubmed/35578835
http://dx.doi.org/10.7554/eLife.73998

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