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The LIN28B/TGF-β/TGFBI feedback loop promotes cell migration and tumour initiation potential in cholangiocarcinoma

Cholangiocarcinoma (CCA), a lethal malignancy of the biliary epithelium, is the second most common primary liver cancer. The poor prognosis of CCA is due to the high rate of tumour invasion and distant metastasis. We found that the RNA-binding protein LIN28B, a known regulator of microRNA biogenesis...

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Detalles Bibliográficos
Autores principales: Puthdee, Nattapong, Sriswasdi, Sira, Pisitkun, Trairak, Ratanasirintrawoot, Sutheera, Israsena, Nipan, Tangkijvanich, Pisit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113936/
https://www.ncbi.nlm.nih.gov/pubmed/34548635
http://dx.doi.org/10.1038/s41417-021-00387-5