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SAF-A mutants disrupt chromatin structure through dominant negative effects on RNAs associated with chromatin

Here we provide a brief review of relevant background before presenting results of our investigation into the interplay between scaffold attachment factor A (SAF-A), chromatin-associated RNAs, and DNA condensation. SAF-A, also termed heterogenous nuclear protein U (hnRNP U), is a ubiquitous nuclear...

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Detalles Bibliográficos
Autores principales: Kolpa, Heather J., Creamer, Kevin M., Hall, Lisa L., Lawrence, Jeanne B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114059/
https://www.ncbi.nlm.nih.gov/pubmed/34859278
http://dx.doi.org/10.1007/s00335-021-09935-8