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D,L-Methadone enhances the cytotoxic activity of standard chemotherapeutic agents on pediatric rhabdomyosarcoma

PURPOSE: In advanced tumor stages, pediatric rhabdomyosarcoma (RMS) shows an intrinsic resistance to standard chemotherapy, which is associated with a dismal prognosis. Alternative therapeutic approaches and optimization of already existent treatment protocols are urgently needed in these conditions...

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Detalles Bibliográficos
Autores principales: Urla, Cristian, Corteletti, Irene, Raible, Ann-Sophie, Handgretinger, Rupert, Fuchs, Jörg, Warmann, Steven W., Schmid, Evi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114081/
https://www.ncbi.nlm.nih.gov/pubmed/35182225
http://dx.doi.org/10.1007/s00432-022-03945-y