Homology directed correction, a new pathway model for point mutation repair catalyzed by CRISPR-Cas

Gene correction is often referred to as the gold standard for precise gene editing and while CRISPR-Cas systems continue to expand the toolbox for clinically relevant genetic repair, mechanistic hurdles still hinder widespread implementation. One of the most prominent challenges to precise CRISPR-di...

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Detalles Bibliográficos
Autores principales: Sansbury, Brett M., Hewes, Amanda M., Tharp, Olivia M., Masciarelli, Sophia B., Kaouser, Salma, Kmiec, Eric B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114366/
https://www.ncbi.nlm.nih.gov/pubmed/35581233
http://dx.doi.org/10.1038/s41598-022-11808-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114366/
https://www.ncbi.nlm.nih.gov/pubmed/35581233
http://dx.doi.org/10.1038/s41598-022-11808-2

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