Novel Starting Points for Human Glycolate Oxidase Inhibitors, Revealed by Crystallography-Based Fragment Screening

Primary hyperoxaluria type I (PH1) is caused by AGXT gene mutations that decrease the functional activity of alanine:glyoxylate aminotransferase. A build-up of the enzyme’s substrate, glyoxylate, results in excessive deposition of calcium oxalate crystals in the renal tract, leading to debilitating...

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Detalles Bibliográficos
Autores principales: Mackinnon, Sabrina R., Bezerra, Gustavo A., Krojer, Tobias, Szommer, Tamas, von Delft, Frank, Brennan, Paul E., Yue, Wyatt W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114433/
https://www.ncbi.nlm.nih.gov/pubmed/35601556
http://dx.doi.org/10.3389/fchem.2022.844598

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114433/
https://www.ncbi.nlm.nih.gov/pubmed/35601556
http://dx.doi.org/10.3389/fchem.2022.844598

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