Generation of a High-Affinity Nanobody Against CD147 for Tumor Targeting and Therapeutic Efficacy Through Conjugating Doxorubicin

CD147, a glycosylated transmembrane protein in the immunoglobulin superfamily, is overexpressed on the surfaces of various tumor cells and promotes cancer cell proliferation, invasion, and metastasis. Nanobodies, characterized by small sizes, high affinities and specificities, and low immunogeniciti...

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Detalles Bibliográficos
Autores principales: Li, Rifei, Zhu, Xinjie, Zhou, Peng, Qiao, Yuehua, Li, Yinqian, Xu, Yice, Shi, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114487/
https://www.ncbi.nlm.nih.gov/pubmed/35603157
http://dx.doi.org/10.3389/fimmu.2022.852700

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114487/
https://www.ncbi.nlm.nih.gov/pubmed/35603157
http://dx.doi.org/10.3389/fimmu.2022.852700

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