Synthesis of New 5′-Norcarbocyclic Aza/Deaza Purine Fleximers - Noncompetitive Inhibitors of E.coli Purine Nucleoside Phosphorylase

A new series of flexible 5′-norcarbocyclic aza/deaza-purine nucleoside analogs were synthesized from 6-oxybicyclo[3.1.0.]hex-2-ene and pyrazole-containing fleximer analogs of heterocyclic bases using the Trost procedure. The compounds were evaluated as potential inhibitors of E. coli purine nucleosi...

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Detalles Bibliográficos
Autores principales: Khandazhinskaya, Anastasia, Fateev, Ilja, Konstantinova, Irina, Esipov, Roman, Polyakov, Konstantin, Seley-Radtke, Katherine, Kochetkov, Sergey, Matyugina, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114674/
https://www.ncbi.nlm.nih.gov/pubmed/35601551
http://dx.doi.org/10.3389/fchem.2022.867587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114674/
https://www.ncbi.nlm.nih.gov/pubmed/35601551
http://dx.doi.org/10.3389/fchem.2022.867587

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