Tyrosine nitration of a humanized anti-cocaine mAb differentially affects ligand binding of cocaine and its metabolites

Tetranitromethane was used to selectively modify tyrosine residues of a humanized anti-cocaine mAb (h2E2), under development for the treatment of cocaine use disorders. The effect of mild tyrosine nitration on the affinity of cocaine and two high affinity cocaine metabolites, cocaethylene and benzoy...

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Detalles Bibliográficos
Autores principales: Kirley, Terence L., Greis, Kenneth D., Norman, Andrew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115314/
https://www.ncbi.nlm.nih.gov/pubmed/35600901
http://dx.doi.org/10.1016/j.bbrep.2022.101278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115314/
https://www.ncbi.nlm.nih.gov/pubmed/35600901
http://dx.doi.org/10.1016/j.bbrep.2022.101278

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