Ruthenium-catalyzed asymmetric hydrogenation of aromatic and heteroaromatic ketones using cinchona alkaloid-derived NNP ligands

A series of cinchona alkaloid-based NNP ligands, including a new one, have been employed for the asymmetric hydrogenation of ketones. By combining ruthenium complexes, various aromatic and heteroaromatic ketones were smoothly reacted, yielding valuable chiral alcohols with extremely high 99.9% ee. M...

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Detalles Bibliográficos
Autores principales: Zhang, Ling, Chen, Qian, Li, Linlin, Jiang, Jian, Sun, Hao, Li, Li, Liu, Ting, Zhang, Lin, Li, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115770/
https://www.ncbi.nlm.nih.gov/pubmed/35702223
http://dx.doi.org/10.1039/d2ra02211g
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author Zhang, Ling
Chen, Qian
Li, Linlin
Jiang, Jian
Sun, Hao
Li, Li
Liu, Ting
Zhang, Lin
Li, Chun
author_facet Zhang, Ling
Chen, Qian
Li, Linlin
Jiang, Jian
Sun, Hao
Li, Li
Liu, Ting
Zhang, Lin
Li, Chun
author_sort Zhang, Ling
collection PubMed
description A series of cinchona alkaloid-based NNP ligands, including a new one, have been employed for the asymmetric hydrogenation of ketones. By combining ruthenium complexes, various aromatic and heteroaromatic ketones were smoothly reacted, yielding valuable chiral alcohols with extremely high 99.9% ee. Moreover, a proposed reaction mechanism was discussed and verified by NMR.
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spelling pubmed-91157702022-06-13 Ruthenium-catalyzed asymmetric hydrogenation of aromatic and heteroaromatic ketones using cinchona alkaloid-derived NNP ligands Zhang, Ling Chen, Qian Li, Linlin Jiang, Jian Sun, Hao Li, Li Liu, Ting Zhang, Lin Li, Chun RSC Adv Chemistry A series of cinchona alkaloid-based NNP ligands, including a new one, have been employed for the asymmetric hydrogenation of ketones. By combining ruthenium complexes, various aromatic and heteroaromatic ketones were smoothly reacted, yielding valuable chiral alcohols with extremely high 99.9% ee. Moreover, a proposed reaction mechanism was discussed and verified by NMR. The Royal Society of Chemistry 2022-05-18 /pmc/articles/PMC9115770/ /pubmed/35702223 http://dx.doi.org/10.1039/d2ra02211g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Zhang, Ling
Chen, Qian
Li, Linlin
Jiang, Jian
Sun, Hao
Li, Li
Liu, Ting
Zhang, Lin
Li, Chun
Ruthenium-catalyzed asymmetric hydrogenation of aromatic and heteroaromatic ketones using cinchona alkaloid-derived NNP ligands
title Ruthenium-catalyzed asymmetric hydrogenation of aromatic and heteroaromatic ketones using cinchona alkaloid-derived NNP ligands
title_full Ruthenium-catalyzed asymmetric hydrogenation of aromatic and heteroaromatic ketones using cinchona alkaloid-derived NNP ligands
title_fullStr Ruthenium-catalyzed asymmetric hydrogenation of aromatic and heteroaromatic ketones using cinchona alkaloid-derived NNP ligands
title_full_unstemmed Ruthenium-catalyzed asymmetric hydrogenation of aromatic and heteroaromatic ketones using cinchona alkaloid-derived NNP ligands
title_short Ruthenium-catalyzed asymmetric hydrogenation of aromatic and heteroaromatic ketones using cinchona alkaloid-derived NNP ligands
title_sort ruthenium-catalyzed asymmetric hydrogenation of aromatic and heteroaromatic ketones using cinchona alkaloid-derived nnp ligands
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115770/
https://www.ncbi.nlm.nih.gov/pubmed/35702223
http://dx.doi.org/10.1039/d2ra02211g
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