Design, synthesis, and evaluation of novel O-alkyl ferulamide derivatives as multifunctional ligands for treating Alzheimer’s disease

Herein, a series of novel O-alkyl ferulamide derivatives were designed and synthesised through the multi-target-directed ligands (MTDLs) strategy. The biological activities in vitro showed that compounds 5a, 5d, 5e, 5f, and 5h indicated significantly selective MAO-B inhibitory potency (IC(50) = 0.32...

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Detalles Bibliográficos
Autores principales: Zhu, Gaofeng, Bai, Ping, Wang, Keren, Mi, Jing, Yang, Jing, Hu, Jiaqi, Ban, Yujuan, Xu, Ran, Chen, Rui, Wang, Changning, Tang, Lei, Sang, Zhipei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116242/
https://www.ncbi.nlm.nih.gov/pubmed/35549612
http://dx.doi.org/10.1080/14756366.2022.2073442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116242/
https://www.ncbi.nlm.nih.gov/pubmed/35549612
http://dx.doi.org/10.1080/14756366.2022.2073442

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