New 1,2,3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization

A series of novel 1,2,3-triazole-linked ciprofloxacin-chalcones 4a-j were synthesised as potential anticancer agents. Hybrids 4a-j exhibited remarkable anti-proliferative activity against colon cancer cells. Compounds 4a-j displayed IC(50)s ranged from 2.53-8.67 µM, 8.67–62.47 µM, and 4.19–24.37 µM...

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Detalles Bibliográficos
Autores principales: Mohammed, Hamada H. H., Abd El-Hafeez, Amer Ali, Ebeid, Kareem, Mekkawy, Aml I., Abourehab, Mohammed A. S., Wafa, Emad I., Alhaj-Suliman, Suhaila O., Salem, Aliasger K., Ghosh, Pradipta, Abuo-Rahma, Gamal El-Din A., Hayallah, Alaa M., Abbas, Samar H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Orginal Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116245/
https://www.ncbi.nlm.nih.gov/pubmed/35548854
http://dx.doi.org/10.1080/14756366.2022.2072308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116245/
https://www.ncbi.nlm.nih.gov/pubmed/35548854
http://dx.doi.org/10.1080/14756366.2022.2072308

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