Discovery of new nicotinamides as apoptotic VEGFR-2 inhibitors: virtual screening, synthesis, anti-proliferative, immunomodulatory, ADMET, toxicity, and molecular dynamic simulation studies

A library of modified VEGFR-2 inhibitors was designed as VEGFR-2 inhibitors. Virtual screening was conducted for the hypothetical library using in silico docking, ADMET, and toxicity studies. Four compounds exhibited high in silico affinity against VEGFR-2 and an acceptable range of the drug-likenes...

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Detalles Bibliográficos
Autores principales: Yousef, Reda G., Ibrahim, Albaraa, Khalifa, Mohamed M., Eldehna, Wagdy M., Gobaara, Ibraheem M. M., Mehany, Ahmed B. M., Elkaeed, Eslam B., Alsfouk, Aisha A., Metwaly, Ahmed M., Eissa, Ibrahim H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116259/
https://www.ncbi.nlm.nih.gov/pubmed/35577416
http://dx.doi.org/10.1080/14756366.2022.2070744

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116259/
https://www.ncbi.nlm.nih.gov/pubmed/35577416
http://dx.doi.org/10.1080/14756366.2022.2070744

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