LRBA Deficiency Can Lead to Lethal Colitis That Is Diminished by SHIP1 Agonism

Humans homozygous for inactivating LRBA (lipopolysaccharide (LPS)-responsive beige-like anchor) mutations or with compound heterozygous mutations exhibit a spectrum of immune-related pathologies including inflammatory bowel disease (IBD). The cause of this pathology remains undefined. Here we show t...

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Detalles Bibliográficos
Autores principales: Sudan, Raki, Fernandes, Sandra, Srivastava, Neetu, Pedicone, Chiara, Meyer, Shea T., Chisholm, John D., Engelman, Robert W., Kerr, William G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116273/
https://www.ncbi.nlm.nih.gov/pubmed/35603158
http://dx.doi.org/10.3389/fimmu.2022.830961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116273/
https://www.ncbi.nlm.nih.gov/pubmed/35603158
http://dx.doi.org/10.3389/fimmu.2022.830961

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